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KMID : 0617319910010010112
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Journal of Pharmacetical Sceiences Ewha Womans University
1991 Volume.1 No. 1 p.112 ~ p.118
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The Effect on the Dissolution Rate of Sulfamerazine from Sugar Glass Dispersion System
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Abstract
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Three sugar glass dispersions of sulfamerazine were prepared using dextrose, galactose and sucrose as the carriers, with the ratio of the drug to the carrier was 1:9.
The chemical stability of sulfamerazine in the glass dispersion system was studied using TLC. TLC revealed no additional spot and there was good correspondence with the Sulfamerazine itself.
While time required to dissolve 50%(T_50%) of sulfamerazine powder was 390 min that of dextrose glass dispersion system was 1.5min. and galactose system was 4.0min. in distilled water 23)
T_50% of physical mixture with dextrose, galactose and sucrose were 26.4min., 26.5min., and 26.0min. respectively in distilled water.
T_50% of control was 54min. and those of all of the glass dispersion systems were within 1min. in 0.1N HCI.
The dissolution rates of sulfamerazine from sugar glass dispersion system in distilled water was greater than that in 0.1N HCI.
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